Epi vs. NorEpi | EVT for BAO | High-dose IN Fentanyl | Post-thrombectomy tPA | Stress of the Stress Test

The JournalFeed podcast for the week of March 21-25, 2022.

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Epi vs. NorEpi Spoon feed:

Continuous epinephrine infusion for post-resuscitation shock in out of hospital cardiac arrest (OHCA) was associated with both higher all-cause and cardiovascular specific mortality when compared to norepinephrine.

EVT for BAO Spoon Feed:

Time from symptom onset of a basilar artery occlusion (BAO) to endovascular therapy (EVT) of less than 6 hours compared to greater than 6 hours (up to 24 hours) was associated with lower odds of in-hospital mortality, disability, symptomatic intracranial hemorrhage, and higher odds of ambulation at discharge, discharge home and reperfusion.

High-dose IN Fentanyl Spoon Feed:

Higher doses of intranasal (IN) fentanyl for pain ranging from 2-5 μg/kg (with a maximum of 200 μg) were given in a pediatric emergency department, with no documented episodes of apnea, hypotension, or respiratory failure.

Post-thrombectomy tPA Spoon Feed:

Among patients with acute ischemic stroke with large vessel occlusion (LVO) that have been successfully reperfused with thrombectomy, the use of post-thrombectomy adjunctive intra-arterial alteplase results in greater likelihood of excellent neurologic outcome at 90 days - modified-Rankin score (mRs) 0 or 1 - when compared with placebo.

Stress of the Stress Test Spoon Feed:

More intense follow-up noninvasive cardiac stress testing within 72 hours among patients with chest pain discharged from the ED was associated with greater major adverse coronary outcomes (MACE) at 60 days, but this was mainly driven by more downstream procedures.